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Safety of minoxidil for hair loss
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J Cutan Med Surg. 2003 Jul-Aug;7(4):322-9.
Safety of topical minoxidil solution: a one-year, prospective, observational study.
Shapiro J.
BACKGROUND: Topical minoxidil solution (TMS) is widely used for androgenetic alopecia (AGA) or male pattern hair loss, and this is the first report of a large safety trial. OBJECTIVES: The aim of the study was to evaluate the safety profile of TMS by comparing hospitalization and death rates among subjects using TMS with controls. Cardiovascular safety and pregnancy outcomes were evaluated, and usage patterns were described. METHODS: All subjects were followed at baseline, 3, 6, 9, and 12 months. Usage patterns, pregnancy status, overnight hospital stays, and cardiovascular risk factors were evaluated. Subjects rated effectiveness of TMS in the treatment of AGA. Statistical analyses were conducted to determine if TMS was associated with an increased risk of death or hospitalization. RESULTS: TMS is a safe and effective treatment for AGA. There were no increases in cardiovascular events and no apparent increased risk for adverse pregnancy outcomes. CONCLUSIONS: This large, prospective study demonstrated the overall safety of TMS in the treatment of AGA.